Data di Pubblicazione:
2011
Abstract:
Placebo analgesia is mediated by both opioid and nonopioid mechanisms, but so far nothing is known about the nonopioid component. Here we show that the specific CB1 cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide (rimonabant or SR141716) blocks nonopioid placebo analgesic responses but has no effect on opioid placebo responses. These findings suggest that the endocannabinoid system has a pivotal role in placebo analgesia in some circumstances when the opioid system is not involved.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Clinical pharmacology, Pain
Elenco autori:
Benedetti F; Amanzio M; Rosato R.; Blanchard C
Link alla scheda completa:
Link al Full Text:
Pubblicato in: