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Priming of the vascularendothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleentyrosine kinase

Articolo
Data di Pubblicazione:
2011
Abstract:
CD36 plays a critical role in the inhibition of angiogenesis through binding to the type 1 repeats of thrombospondin-1 (TSP-1) and activating Fyn tyrosine kinase and MAPK pathways. Here, we reveal a novel association of CD36 with VEGFR-2 and spleen tyrosine kinase (Syk). We also address the correlation between the expression of CD36 and Syk by demonstrating that overexpression of CD36 in HUVECs up-regulates endogenous Syk expression. We also define a new role for TSP-1 and CD36 in the activation of the VEGFR-2 signaling pathway that requires Syk. Our findings also identify a role for Syk as a stimulator of VEGF-A-induced angiogenesis by increasing phosphorylation of Y1175 in VEGFR-2, which is a major tyrosine for promoting VEGF-A-induced endothelial cell migration. Together, these studies introduce a new signaling pathway for TSP-1, CD36, and Syk, and address the role of these proteins in regulating the angiogenic switch.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
angiogenesis; cell adhesion
Elenco autori:
Kazerounian S; Duquette M; Reyes MA; Lawler JT; Song K; Perruzzi C; Primo L; Khosravi-Far R; Bussolino F; Rabinovitz I; Lawler J.
Autori di Ateneo:
PRIMO Luca
Link alla scheda completa:
https://iris.unito.it/handle/2318/101313
Pubblicato in:
BLOOD
Journal
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