Data di Pubblicazione:
2012
Abstract:
The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation has laid the foundation for a molecular based recognition of anaplastic large cell lymphoma and highlighted the need for a further stratification of T-cell neoplasia. Likewise the detection of anaplastic lymphoma kinase (ALK) genetic lesions among many human cancers has defined unique subsets of cancer patients, providing new opportunities for innovative therapeutic interventions. The objective of this review is to appraise the molecular mechanisms driving ALK-mediated transformation, and to maintain the neoplastic phenotype. The understanding of these events will allow the design and implementation of novel tailored strategies for a well-defined subset of cancer patients.
Tipologia CRIS:
03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica
Elenco autori:
Tabbó F; Barreca A; Piva R; Inghirami G; The European T-Cell Lymphoma Study Group; including; Riccardo Bruna; Daniele Corino; Diego Cortese; Ramona Crescenzo; Giuditta Cuccuru; Filomena di Giacomo; Alessandro Fioravanti; Marco Ladetto; Indira Landra; Katia Messana; Rodolfo Machiorlatti; Barbara Martinoglio; Enzo Medico; Marta Mossino; Elisa Pellegrino; Maria Todaro; Paola Campisi; Luigi Chiusa; Annalisa Chiappella; Domenico Novero; Umberto Vitolo; Francesco Abate; Andrea Acquaviva; Elisa Ficarra; Roberto Freilone; Marco Chilosi; Alberto Zamó; Fabio Facchetti; Silvia Lonardi; Anna De Chiara; Franco Fulciniti; Claudio Doglioni; Maurilio Ponzoni; Luca Agnelli; Antonino Neri; Katia Todoerti; Claudio Agostinelli; Pier Paolo Piccaluga; Stefano Pileri; Brunangelo Falini; Enrico Tiacci; Peter Van Loo; Thomas Tousseyn; Christiane De Wolf-Peeters; Eva Geissinger; Hans Konrad Muller-Hermelink; Andreas Rosenwald; Miguel Angel Piris; Maria E. Rodriguez; Francesco Bertoni; Michela Boi; Ivo Kwee;)
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