New Formulation of Functionalized Bioactive Glasses to Be Used as Carriers for the Development of pH-Stimuli Responsive Biomaterials for Bone Diseases
Articolo
Data di Pubblicazione:
2014
Abstract:
The aim of the present contribution is to prepare a
functionalized bioactive glass potentially useful as prosthetic material,
but also able to release organic molecules in response to a change of the
pH environment. By this approach it is possible to develop devices
which can be used for a triggered drug release in response to specific
stimuli; this is an attractive research field, in order to avoid either
systemic and/or local toxic effects of drugs. In particular, in the present
paper we report data related to the development of a new formulation of
bioactive glasses, their functionalization with organic molecules to obtain
a pH-sensitive bond, their physicochemical characterization and in vitro
bioactivity in simulated biological fluids (SBF), and organic molecule
delivery tests at different pH. The glass functionalization, by means of a
covalent reaction, allows us to produce a model of pH-responsive
bioactive biomaterial: when it is exposed to specific pH changes, it can
favor the release of the organic molecules directly at the target site. Cysteamine and 5-aminofluorescein are used as model
molecules to simulate a drug. The materials, before and after the different functionalization steps and in vitro release tests at
different pH, have been characterized by means of different experimental techniques such as X-ray powder diffraction (XRPD), Raman, FTIR and fluorescence spectroscopies, N2 adsorption, thermogravimetric (TGA) and elemental analysis.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Functionalized Bioactive Glasses; pH-Stimuli Responsive Biomaterials; conjugation
Elenco autori:
Valentina Aina; Claudio Magistris; Giuseppina Cerrato; Gianmario Martra; Guido Viscardi; Gigliola Lusvardi; Gianluca Malavasi; Ledi Menabue
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