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Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming

Articolo
Data di Pubblicazione:
2015
Abstract:
Growing evidence suggests that transcriptional regulators and secreted RNA molecules encapsulated within membrane vesicles modify the phenotype of target cells. Membrane vesicles, actively released by cells, represent a mechanism of intercellular communication that is conserved evolutionarily and involves the transfer of molecules able to induce epigenetic changes in recipient cells. Extracellular vesicles, which include exosomes and microvesicles, carry proteins, bioactive lipids, and nucleic acids, which are protected from enzyme degradation. These vesicles can transfer signals capable of altering cell function and/or reprogramming targeted cells. In the present review we focus on the extracellular vesicle-induced epigenetic changes in recipient cells that may lead to phenotypic and functional modifications. The relevance of these phenomena in stem cell biology and tissue repair is discussed.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
extracellular RNA, exosomes, microvesicles
Elenco autori:
Quesenberry, Peter J; Aliotta, Jason; Deregibus, Maria Chiara; Camussi, Giovanni
Link alla scheda completa:
https://iris.unito.it/handle/2318/1574495
Pubblicato in:
STEM CELL RESEARCH & THERAPY
Journal
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