Synthesis of Trimethyl a -Keto Trithioorthoesters and Dimethyl a -Keto Dithioacetals by Reaction of Acyl Chlorides, Anhydrides, Thiol Esters, and N,N-Dimethylamides with [Tris(methylthio)methyl]lithium

In the present research was made a study of the reactions of [tris(methylthio)methyl]lithium (6) with representative aromatic and aliphatic acyl chlorides 2, anhydrides 3, thiol esters 4, and N,N-dimethylamides 5 for use as starting compounds, alternative to esters 1, for the preparation of trimethyl R-keto trithioortoesters 8 and dimethyl R-keto dithioacetals 7 (Scheme 1).