N-Functionalization of Azoles via Coupling Reactions with Alkoxydienyl and Alkoxystyryl Boronic Esters

Alkoxydienyl boronates 1a and 1b and alkoxystyryl boronate 2 have been used in various copper mediated cross-coupling reactions with azoles. A variety of N-alkoxydienyl- and Nstyrylazoles have been synthesized under mild conditions. The process utilizes Cu(OAc)2 in the presence of CsF in CH2Cl2 at room temperature.