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Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

Articolo
Data di Pubblicazione:
2019
Abstract:
The progression of chronic liver diseases (CLD), irrespective of etiology, involves chronic parenchymal injury, persistent activation of inflammatory response as well as sustained activation of liver fibrogenesis and wound healing response. Liver fibrogenesis, is a dynamic, highly integrated molecular, cellular and tissue process responsible for driving the excess accumulation of extracellular matrix (ECM) components (i.e., liver fibrosis) sustained by an eterogeneous population of hepatic myofibroblasts (MFs). The process of liver fibrogenesis recognizes a number of common and etiology-independent mechanisms and events but it is also significantly influenced by the specific etiology, as also reflected by peculiar morphological patterns of liver fibrosis development. In this review we will analyze the most relevant established and/or emerging pathophysiological issues underlying CLD progression with a focus on the role of critical hepatic cell populations, mechanisms and signaling pathways involved, as they represent potential therapeutic targets, to finally analyze selected and relevant clinical issues.
Tipologia CRIS:
03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica
Keywords:
Hepatic myofibroblasts; Hepatic stellate cells; Liver biopsy; Liver fibrosis; Transient elestography; Biochemistry; Molecular Medicine; Molecular Biology; Clinical Biochemistry
Elenco autori:
Parola, Maurizio*; Pinzani, Massimo
Autori di Ateneo:
PAROLA Maurizio
Link alla scheda completa:
https://iris.unito.it/handle/2318/1689992
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1689992/506115/Mol%20Aspects%20Med%20-%20post%20print.pdf
Pubblicato in:
MOLECULAR ASPECTS OF MEDICINE
Journal
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URL

www.elsevier.com/locate/mam
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