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Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis

Articolo
Data di Pubblicazione:
2019
Abstract:
Background: Transient receptor potential (TRP) channels control multiple processes involved in cancer progression by modulating cell proliferation, survival, invasion and intravasation, as well as, endothelial cell (EC) biology and tumor angiogenesis. Nonetheless, a complete TRP expression signature in tumor vessels, including in prostate cancer (PCa), is still lacking. Methods: In the present study, we profiled by qPCR the expression of all TRP channels in human prostate tumor-derived ECs (TECs) in comparison with TECs from breast and renal tumors. We further functionally characterized the role of the 'prostate-associated' channels in proliferation, sprout formation and elongation, directed motility guiding, as well as in vitro and in vivo morphogenesis and angiogenesis. Results: We identified three 'prostate-associated' genes whose expression is upregulated in prostate TECs: TRPV2 as a positive modulator of TEC proliferation, TRPC3 as an endothelial PCa cell attraction factor and TRPA1 as a critical TEC angiogenic factor in vitro and in vivo. Conclusions: We provide here the full TRP signature of PCa vascularization among which three play a profound effect on EC biology. These results contribute to explain the aggressive phenotype previously observed in PTEC and provide new putative therapeutic targets.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
TRP; calcium channel; migration; prostate cancer; tumor angiogenesis
Elenco autori:
Bernardini, Michela; Brossa, Alessia; Chinigo, Giorgia; Grolez, Guillaume P; Trimaglio, Giulia; Allart, Laurent; Hulot, Audrey; Marot, Guillemette; Genova, Tullio; Joshi, Aditi; Mattot, Virginie; Fromont, Gaelle; Munaron, Luca; Bussolati, Benedetta; Prevarskaya, Natalia; Fiorio Pla, Alessandra; Gkika, Dimitra
Autori di Ateneo:
BROSSA Alessia
BUSSOLATI Benedetta
FIORIO PLA Alessandra
GENOVA Tullio
MUNARON Luca Maria
Link alla scheda completa:
https://iris.unito.it/handle/2318/1707127
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1707127/520298/Bernardini%20et%20al_2019.pdf
Pubblicato in:
CANCERS
Journal
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URL

https://www.mdpi.com/2072-6694/11/7/956
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