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  1. Pubblicazioni

Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy

Articolo
Data di Pubblicazione:
2019
Abstract:
Nuclear-cytoplasmic shuttling is a highly regulated and complex process, which involves both proteins and nucleic acids. Changes in cellular compartmentalization of various proteins, including oncogenes and tumor suppressors, affect cellular behavior, promoting or inhibiting proliferation, apoptosis and sensitivity to therapies. In this review, we will recapitulate the role of various shuttling components in Chronic Myeloid Leukemia and we will provide insights on the potential role of shuttling proteins as therapeutic targets.
Tipologia CRIS:
03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica
Keywords:
BCR-ABL; PTEN; chronic myeloid leukemia; miRNA; nuclear-cytoplasmic shuttling; p53
Elenco autori:
Carrà, Giovanna; Russo, Isabella; Guerrasio, Angelo; Morotti, Alessandro
Autori di Ateneo:
MOROTTI Alessandro
RUSSO Isabella
Link alla scheda completa:
https://iris.unito.it/handle/2318/1719482
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1719482/553869/cells-08-01248.pdf
Pubblicato in:
CELLS
Journal
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