Skip to Main Content (Press Enter)

Logo UNITO
  • ×
  • Home
  • Pubblicazioni
  • Progetti
  • Persone
  • Competenze
  • Settori
  • Strutture
  • Terza Missione

UNI-FIND
Logo UNITO

|

UNI-FIND

unito.it
  • ×
  • Home
  • Pubblicazioni
  • Progetti
  • Persone
  • Competenze
  • Settori
  • Strutture
  • Terza Missione
  1. Pubblicazioni

Enhanced Killing of Candida krusei by Polymorphonuclear Leucocytes in the Presence of Subinhibitory Concentrations of Melaleuca alternifolia and “Mentha of Pancalieri” Essential Oils

Articolo
Data di Pubblicazione:
2019
Abstract:
The aim of this study was to evaluate the influence of tea tree oil (TTO) and “Mentha of Pancalieri” essential oil (MPP) on intracellular killing of Candida krusei, often resistant to conventional drugs, by polymorphonuclear leucocytes (PMNs). Intracellular killing was investigated by incubating yeasts and PMNs with essential oils (EOs) at 1/4 and 1/8 × MIC (Minimal Inhibitory Concentration), in comparison with anidulafungin, used as a reference drug. Killing values were expressed as Survival Index (SI) values. The cytotoxicity of EOs was evaluated by 3-[4,-5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. Both EOs were more efficaceous at 1/8 × MIC than 1/4 × MIC, with killing values higher than observed in EO-free systems and in presence of anidulafungin, indicating that the decreasing concentrations did not cause lower candidacidal activity. This better activity at 1/8 × MIC is probably due to the EOs’ toxicity at 1/4 × MIC, suggesting that at higher concentrations EOs might interfere with PMNs functionality. TTO and MPP at 1/8 × MIC significantly increased intracellular killing by PMNs through their direct action on the yeasts (both EOs) or on phagocytic cells (MPP), suggesting a positive interaction between EOs and PMNs to eradicate intracellular C. krusei. These data showed a promising potential application of TTO and “Mentha of Pancalieri” EO as natural adjuvants in C. krusei infection management.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Candida krusei, PMNs, intracellular killing, essential oils, TTO, “Mentha of Pancalieri” EO
Elenco autori:
V. Tullio, J.Roana, D. Scalas, N. Mandras
Autori di Ateneo:
MANDRAS Narcisa
ROANA Janira
Link alla scheda completa:
https://iris.unito.it/handle/2318/1720135
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1720135/555775/molecules-24-03824.pdf
Pubblicato in:
MOLECULES
Journal
  • Dati Generali

Dati Generali

URL

https://www.mdpi.com/1420-3049/24/21/3824
  • Utilizzo dei cookie

Realizzato con VIVO | Designed by Cineca | 25.5.0.1