Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch
Articolo
Data di Pubblicazione:
2019
Abstract:
Acton et al. identify the excitatory neurons in the dorsal spinal cord that drive mechanical itch. These cells mediate responses to light punctate touch and are inhibited by neuropeptide Y (NPY)::Cre interneurons. Light touch sensitivity and mechanical itch responses are gated by NPY signaling mediated by Y1-expressing neurons in the dorsal horn.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
chemical itch; dorsal spinal cord; inhibition; mechanical itch transmission; neuropeptide Y; NPY1R signaling; pain; somatosensory processing; touch; Y1 excitatory neurons
Elenco autori:
Acton D.; Ren X.; Di Costanzo S.; Dalet A.; Bourane S.; Bertocchi I.; Eva C.; Goulding M.
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