Beyond oncological hyperthermia: Physically drivable magnetic nanobubbles as novel multipurpose theranostic carriers in the central nervous system
Articolo
Data di Pubblicazione:
2020
Abstract:
Magnetic Oxygen-Loaded Nanobubbles (MOLNBs), manufactured by adding Superparamagnetic Iron Oxide Nanoparticles (SPIONs) on the surface of polymeric nanobubbles, are investigated as theranostic carriers for delivering oxygen and chemotherapy to brain tumors. Physicochemical and cyto-toxicological properties and in vitro internalization by human brain microvascular endothelial cells as well as the motion of MOLNBs in a static magnetic field were investigated. MOLNBs are safe oxygen-loaded vectors able to overcome the brain membranes and drivable through the Central Nervous System (CNS) to deliver their cargoes to specific sites of interest. In addition, MOLNBs are monitorable either via Magnetic Resonance Imaging (MRI) or Ultrasound (US) sonography. MOLNBs can find application in targeting brain tumors since they can enhance conventional radiotherapy and deliver chemotherapy being driven by ad hoc tailored magnetic fields under MRI and/or US monitoring.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Brain barriers;magneticdriving; Brain tumors; Magnetic nanoparticles; Nanobubbles; Theranostic
Elenco autori:
Ficiara E.; Ansari S.A.; Argenziano M.; Cangemi L.; Monge C.; Cavalli R.; D'Agata F.
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