Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
Articolo
Data di Pubblicazione:
2020
Abstract:
Cortical thickness, surface area and volumes vary with age and cognitive function, and in
neurological and psychiatric diseases. Here we report heritability, genetic correlations and
genome-wide associations of these cortical measures across the whole cortex, and in 34
anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20
cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology
(CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between
cortical measures and brain regions, and 160 genome-wide significant associations pointing
to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes
involved in anthropometric traits, hindbrain development, vascular and neurodegenerative
disease and psychiatric conditions. These data are a rich resource for studies of the biological
mechanisms behind cortical development and aging.
Tipologia CRIS:
03A-Articolo su Rivista
Elenco autori:
Hofer, Edith; Roshchupkin, Gennady V.; Adams, Hieab H. H.; Knol, Maria J.; Lin, Honghuang; Li, Shuo; Zare, Habil; Ahmad, Shahzad; Armstrong, Nicola J.; Satizabal, Claudia L.; Bernard, Manon; Bis, Joshua C.; Gillespie, Nathan A.; Luciano, Michelle; Mishra, Aniket; Scholz, Markus; Teumer, Alexander; Xia, Rui; Jian, Xueqiu; Mosley, Thomas H.; Saba, Yasaman; Pirpamer, Lukas; Seiler, Stephan; Becker, James T.; Carmichael, Owen; Rotter, Jerome I.; Psaty, Bruce M.; Lopez, Oscar L.; Amin, Najaf; van der Lee, Sven J.; Yang, Qiong; Himali, Jayandra J.; Maillard, Pauline; Beiser, Alexa S.; DeCarli, Charles; Karama, Sherif; Lewis, Lindsay; Harris, Mat; Bastin, Mark E.; Deary, Ian J.; Veronica Witte, A.; Beyer, Frauke; Loeffler, Markus; Mather, Karen A.; Schofield, Peter R.; Thalamuthu, Anbupalam; Kwok, John B.; Wright, Margaret J.; Ames, David; Trollor, Julian; Jiang, Jiyang; Brodaty, Henry; Wen, Wei; Vernooij, Meike W.; Hofman, Albert; Uitterlinden, André G.; Niessen, Wiro J.; Wittfeld, Katharina; Bülow, Robin; Völker, Uwe; Pausova, Zdenka; Bruce Pike, G.; Maingault, Sophie; Crivello, Fabrice; Tzourio, Christophe; Amouyel, Philippe; Mazoyer, Bernard; Neale, Michael C.; Franz, Carol E.; Lyons, Michael J.; Panizzon, Matthew S.; Andreassen, Ole A.; Dale, Anders M.; Logue, Mark; Grasby, Katrina L.; Jahanshad, Neda; Painter, Jodie N.; Colodro-Conde, Lucía; Bralten, Janita; Hibar, Derrek P.; Lind, Penelope A.; Pizzagalli, Fabrizio; Stein, Jason L.; Thompson, Paul M.; Medland, Sarah E.; Sachdev, Perminder S.; Kremen, William S.; Wardlaw, Joanna M.; Villringer, Arno; van Duijn, Cornelia M.; Grabe, Hans J.; Longstreth, William T.; Fornage, Myriam; Paus, Tomas; Debette, Stephanie; Arfan Ikram, M.; Schmidt, Helena; Schmidt, Reinhold; Seshadri, Sudha
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