An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates
Articolo
Data di Pubblicazione:
2020
Abstract:
Goveia et al. use single-cell RNA sequencing to provide an inventory of tumor endothelial cell (TEC) phenotypes from human and mouse non-small cell lung cancer and validate them functionally. Specific TEC phenotypes are associated with prognosis and response to anti-angiogenic therapy.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
angiogenesis; anti-angiogenic therapy; cancer; endothelial cells; endothelial heterogeneity; multi-omics; single-cell RNA sequencing; Angiogenesis Inhibitors; Animals; Basement Membrane; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cluster Analysis; Collagen; Endothelial Cells; Endothelium, Vascular; Female; Humans; Lung Neoplasms; Male; Mice; Phenotype; Single-Cell Analysis; Vascular Endothelial Growth Factor A; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Neovascularization, Pathologic
Elenco autori:
Goveia J.; Rohlenova K.; Taverna F.; Treps L.; Conradi L.-C.; Pircher A.; Geldhof V.; de Rooij L.P.M.H.; Kalucka J.; Sokol L.; Garcia-Caballero M.; Zheng Y.; Qian J.; Teuwen L.-A.; Khan S.; Boeckx B.; Wauters E.; Decaluwe H.; De Leyn P.; Vansteenkiste J.; Weynand B.; Sagaert X.; Verbeken E.; Wolthuis A.; Topal B.; Everaert W.; Bohnenberger H.; Emmert A.; Panovska D.; De Smet F.; Staal F.J.T.; Mclaughlin R.J.; Impens F.; Lagani V.; Vinckier S.; Mazzone M.; Schoonjans L.; Dewerchin M.; Eelen G.; Karakach T.K.; Yang H.; Wang J.; Bolund L.; Lin L.; Thienpont B.; Li X.; Lambrechts D.; Luo Y.; Carmeliet P.
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