Skip to Main Content (Press Enter)

Logo UNITO
  • ×
  • Home
  • Pubblicazioni
  • Progetti
  • Persone
  • Competenze
  • Settori
  • Strutture
  • Terza Missione

UNI-FIND
Logo UNITO

|

UNI-FIND

unito.it
  • ×
  • Home
  • Pubblicazioni
  • Progetti
  • Persone
  • Competenze
  • Settori
  • Strutture
  • Terza Missione
  1. Pubblicazioni

Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

Articolo
Data di Pubblicazione:
2020
Abstract:
We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n = ~ 38,000 for LTL and ~ 81,000 for ALS in the European population; n = ~ 23,000 for LTL and ~ 4,100 for ALS in the Asian population). We further evaluated mediation roles of lipids in the pathway from LTL to ALS. The odds ratio per standard deviation decrease of LTL on ALS was 1.10 (95% CI 0.93–1.31, p = 0.274) in the European population and 0.75 (95% CI 0.53–1.07, p = 0.116) in the Asian population. This null association was also detected between LTL and frontotemporal dementia in the European population. However, we found that an indirect effect of LTL on ALS might be mediated by low density lipoprotein (LDL) or total cholesterol (TC) in the European population. These results were robust against extensive sensitivity analyses. Overall, our MR study did not support the direct causal association between LTL and the ALS risk in neither population, but provided suggestive evidence for the mediation role of LDL or TC on the influence of LTL and ALS in the European population.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Amyotrophic Lateral Sclerosis; Asian Continental Ancestry Group; Cholesterol; European Continental Ancestry Group; Genome-Wide Association Study; Humans; Leukocytes; Lipoproteins, LDL; Odds Ratio; Polymorphism, Single Nucleotide; Proportional Hazards Models; Telomerase; Telomere; Telomere Shortening; Frontotemporal Dementia; Mendelian Randomization Analysis
Elenco autori:
Gao Y.; Wang T.; Yu X.; Ferrari R.; Hernandez D.G.; Nalls M.A.; Rohrer J.D.; Ramasamy A.; Kwok J.B.J.; Dobson-Stone C.; Brooks W.S.; Schofield P.R.; Halliday G.M.; Hodges J.R.; Piguet O.; Bartley L.; Thompson E.; Haan E.; Hernandez I.; Ruiz A.; Boada M.; Borroni B.; Padovani A.; Cruchaga C.; Cairns N.J.; Benussi L.; Binetti G.; Ghidoni R.; Forloni G.; Albani D.; Galimberti D.; Fenoglio C.; Serpente M.; Scarpini E.; Clarimon J.; Lleo A.; Blesa R.; Waldo M.L.; Nilsson K.; Nilsson C.; Mackenzie I.R.A.; Hsiung G.-Y.R.; Mann D.M.A.; Grafman J.; Morris C.M.; Attems J.; Griffiths T.D.; McKeith I.G.; Thomas A.J.; Pietrini P.; Huey E.D.; Wassermann E.M.; Baborie A.; Jaros E.; Tierney M.C.; Pastor P.; Razquin C.; Ortega-Cubero S.; Alonso E.; Perneczky R.; Diehl-Schmid J.; Alexopoulos P.; Kurz A.; Rainero I.; Rubino E.; Pinessi L.; Rogaeva E.; George-Hyslop P.S.; Rossi G.; Tagliavini F.; Giaccone G.; Rowe J.B.; Schlachetzki J.C.M.; Uphill J.; Collinge J.; Mead S.; Danek A.; Van Deerlin V.M.; Grossman M.; Trojanowski J.Q.; van der Zee J.; Cruts M.; Van Broeckhoven C.; Cappa S.F.; Leber I.; Hannequin D.; Golfier V.; Vercelletto M.; Brice A.; Nacmias B.; Sorbi S.; Bagnoli S.; Piaceri I.; Nielsen J.E.; Hjermind L.E.; Riemenschneider M.; Mayhaus M.; Ibach B.; Gasparoni G.; Pichler S.; Gu W.; Rossor M.N.; Fox N.C.; Warren J.D.; Spillantini M.G.; Morris H.R.; Rizzu P.; Heutink P.; Snowden J.S.; Rollinson S.; Richardson A.; Gerhard A.; Bruni A.C.; Maletta R.; Frangipane F.; Cupidi C.; Bernardi L.; Anfossi M.; Gallo M.; Conidi M.E.; Smirne N.; Rademakers R.; Baker M.; Dickson D.W.; Graff-Radford N.R.; Petersen R.C.; Knopman D.; Josephs K.A.; Boeve B.F.; Parisi J.E.; Seeley W.W.; Miller B.L.; Karydas A.M.; Rosen H.; van Swieten J.C.; Dopper E.G.P.; Seelaar H.; Pijnenburg Y.A.L.; Scheltens P.; Logroscino G.; Capozzo R.; Novelli V.; Puca A.A.; Franceschi M.; Postiglione A.; Milan G.; Sorrentino P.; Kristiansen M.; Chiang H.-H.; Graff C.; Pasquier F.; Rollin A.; Deramecourt V.; Lebouvier T.; Kapogiannis D.; Ferrucci L.; Pickering-Brown S.; Singleton A.B.; Hardy J.; Momeni P.; Zhao H.; Zeng P.
Autori di Ateneo:
RAINERO Innocenzo
RUBINO Elisa
Link alla scheda completa:
https://iris.unito.it/handle/2318/1783265
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1783265/745113/41598_2020_Article_68848_Gao.pdf
Pubblicato in:
SCIENTIFIC REPORTS
Journal
  • Utilizzo dei cookie

Realizzato con VIVO | Designed by Cineca | 25.6.1.0