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Role of rhBMP-7, Fibronectin, And Type I Collagen in Dental Implant Osseointegration Process: An Initial Pilot Study on Minipig Animals

Articolo
Data di Pubblicazione:
2021
Abstract:
Background: The biological factors involved in dental implant osseointegration need to be investigated to improve implant success. Methods: Twenty-four implants were inserted into the tibias of six minipigs. Bone samples were obtained at 7, 14, and 56 days. Biomolecular analyses evaluated mRNA of BMP-4, -7, Transforming Growth Factor-beta2, Interleukin-1beta, and Osteocalcin in sites treated with rhBMP-7, Type 1 Collagen, or Fibronectin (FN). Inflammation and osteogenesis were evaluated by histological analyses. Results: At 7 and 14 days, BMP-4 and BMP-7 increased in the sites prepared with rhBMP-7 and FN. BMP-7 remained greater at 56 days in rhBMP-7 and FN sites. BPM-4 at 7 and 14 days increased in Type 1 Collagen sites; BMP-7 increased from day 14. FN increased the TGF-beta2 at all experimental times, whilst the rhBMP-7 only did so up to 7 days. IL-1beta increased only in collagen-treated sites from 14 days. Osteocalcin was high in FN-treated sites. Neutrophilic granulocytes characterized the inflammatory infiltrate at 7 days, and mononuclear cells at 14 and 56 days. Conclusions: This initial pilot study, in a novel way, evidenced that Type 1 Collagen induced inflammation and did not stimulate bone production; conversely FN or rhBMP-7 showed neo-osteogenetic and anti-inflammatory properties when directly added into implant bone site.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
dental implant, fibronectin, rhBMP-7, type 1 collagen, cytokines, bone morphogenetic proteins
Elenco autori:
Schierano, Gianmario; Canuto, Rosa Angela; Mauthe von Degerfeld, Mitzy; Navone, Roberto; Peirone, Bruno; Preti, Giulio; Muzio, Giuliana
Autori di Ateneo:
MAUTHE DEGERFELD Mitzy
MUZIO Giuliana
PEIRONE Bruno
SCHIERANO Gianmario
Link alla scheda completa:
https://iris.unito.it/handle/2318/1788027
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1788027/758772/materials-14-02185.pdf
Pubblicato in:
MATERIALS
Journal
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Dati Generali

URL

https://doi.org/10.3390/ma14092185
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