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  1. Pubblicazioni

The Oncogene Transcription Factor EB Regulates Vascular Functions

Articolo
Data di Pubblicazione:
2021
Abstract:
Transcription factor EB (TFEB) represents an emerging player in vascular biology. It belongs to the bHLH-leucine zipper transcription factor microphthalmia family, which includes microphthalmia-associated transcription factor, transcription factor E3 and transcription factor EC, and is known to be deregulated in cancer. The canonical transcriptional pathway orchestrated by TFEB adapts cells to stress in all kinds of tissues by supporting lysosomal and autophagosome biogenesis. However, emerging findings highlight that TFEB activates other genetic programs involved in cell proliferation, metabolism, inflammation and immunity. Here, we first summarize the general principles and mechanisms by which TFEB activates its transcriptional program. Then, we analyze the current knowledge of TFEB in the vascular system, placing particular emphasis on its regulatory role in angiogenesis and on the involvement of the vascular unit in inflammation and atherosclerosis.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
angiogenesis; autophagy; cell cycle; embryo; inflammation
Elenco autori:
Doronzo G.; Astanina E.; Bussolino F.
Autori di Ateneo:
ASTANINA Elena
DORONZO Gabriella
Link alla scheda completa:
https://iris.unito.it/handle/2318/1789507
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1789507/762587/fphys-12-640061%20(1).pdf
Pubblicato in:
FRONTIERS IN PHYSIOLOGY
Journal
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