Skip to Main Content (Press Enter)

Logo UNITO
  • ×
  • Home
  • Pubblicazioni
  • Progetti
  • Persone
  • Competenze
  • Settori
  • Strutture
  • Terza Missione

UNI-FIND
Logo UNITO

|

UNI-FIND

unito.it
  • ×
  • Home
  • Pubblicazioni
  • Progetti
  • Persone
  • Competenze
  • Settori
  • Strutture
  • Terza Missione
  1. Pubblicazioni

Immune Trait Shifts in Association With Tobacco Smoking: A Study in Healthy Women

Articolo
Data di Pubblicazione:
2021
Abstract:
Tobacco smoking is known to impact circulating levels of major immune cells populations, but its effect on specific immune cell subsets remains poorly understood. Here, using high-resolution data from 223 healthy women (25 current and 198 never smokers), we investigated the association between smoking status and 35,651 immune traits capturing immune cell subset frequencies. Our results confirmed that active tobacco smoking is associated with increased frequencies of circulating CD8+ T cells expressing the CD25 activation marker. Moreover, we identified novel associations between smoking status and relative abundances of CD8+ CD25+ memory T cells, CD8+ memory T cells expressing the CCR4 chemokine receptor, and CD4+CD8+ (double-positive) CD25+ T cells. We also observed, in current smokers, a decrease in the relative frequencies of CD4+ T cells expressing the CD38 activation marker and an increase in class-switched memory B cell isotypes IgA, IgG, and IgE. Finally, using data from 135 former female smokers, we showed that the relative frequencies of immune traits associated with active smoking are usually completely restored after smoking cessation, with the exception of subsets of CD8+ and CD8+ memory T cells, which persist partially altered. Our results are consistent with previous findings and provide further evidence on how tobacco smoking shapes leukocyte cell subsets proportion toward chronic inflammation.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
epidemiology; immune cell subset frequencies; immune traits; leukocyte-shift; tobacco smoking exposure
Elenco autori:
Piaggeschi G.; Rolla S.; Rossi N.; Brusa D.; Naccarati A.; Couvreur S.; Spector T.D.; Roederer M.; Mangino M.; Cordero F.; Falchi M.; Visconti A.
Autori di Ateneo:
CORDERO Francesca
ROLLA Simona
VISCONTI Alessia
Link alla scheda completa:
https://iris.unito.it/handle/2318/1801531
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1801531/801021/2021%20Piaggeschi%20et%20al.%20fimmu.pdf
Pubblicato in:
FRONTIERS IN IMMUNOLOGY
Journal
  • Dati Generali
  • Aree Di Ricerca

Dati Generali

URL

https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.637974/full

Aree Di Ricerca

Settori (17)


LS2_11 - Bioinformatics and computational biology - (2022)

LS6_1 - Innate immunity - (2022)

LS6_2 - Adaptive immunity - (2022)

CIBO, AGRICOLTURA e ALLEVAMENTI - Agricoltura e Produzioni Vegetali

CIBO, AGRICOLTURA e ALLEVAMENTI - Allevamento e Produzioni Animali

CIBO, AGRICOLTURA e ALLEVAMENTI - Farmacologia Veterinaria

CIBO, AGRICOLTURA e ALLEVAMENTI - Miglioramento e difesa delle colture

CIBO, AGRICOLTURA e ALLEVAMENTI - Patologia e malattie degli animali

CIBO, AGRICOLTURA e ALLEVAMENTI - Scienze cliniche veterinarie

CIBO, AGRICOLTURA e ALLEVAMENTI - Tecnologie alimentari e microbiologia degli alimenti

INFORMATICA, AUTOMAZIONE e INTELLIGENZA ARTIFICIALE - Genetica, Omica e Bioinformatica

MEDICINA, SALUTE e BENESSERE - Epidemiologia

MEDICINA, SALUTE e BENESSERE - Malattie neurologiche e neurodegenerative

MEDICINA, SALUTE e BENESSERE - Oncologia e Tumori

MEDICINA, SALUTE e BENESSERE - Ricerca Traslazionale e Clinica

MEDICINA, SALUTE e BENESSERE - Trapianti e medicina rigenerativa

SCIENZE DELLA VITA e FARMACOLOGIA - Interazioni tra molecole, cellule, organismi e ambiente
  • Utilizzo dei cookie

Realizzato con VIVO | Designed by Cineca | 25.5.3.0