Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data
Articolo
Data di Pubblicazione:
2021
Abstract:
The brain systems underlying placebo analgesia are insufficiently understood. Here we performed a systematic, participant-level meta-analysis of experimental functional neuroimaging studies of evoked pain under stimulus-intensity-matched placebo and control conditions, encompassing 603 healthy participants from 20 (out of 28 eligible) studies. We find that placebo vs. control treatments induce small, widespread reductions in pain-related activity, particularly in regions belonging to ventral attention (including mid-insula) and somatomotor networks (including posterior insula). Behavioral placebo analgesia correlates with reduced pain-related activity in these networks and the thalamus, habenula, mid-cingulate, and supplementary motor area. Placebo-associated activity increases occur mainly in frontoparietal regions, with high between-study heterogeneity. We conclude that placebo treatments affect pain-related activity in multiple brain areas, which may reflect changes in nociception and/or other affective and decision-making processes surrounding pain. Between-study heterogeneity suggests that placebo analgesia is a multi-faceted phenomenon involving multiple cerebral mechanisms that differ across studies.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Adult; Behavior; Brain; Female; Humans; Image Enhancement; Male; Nervous System; Pain; Placebos; Analgesia; Magnetic Resonance Imaging
Elenco autori:
Zunhammer M.; Spisak T.; Wager T.D.; Bingel U.; Atlas L.; Benedetti F.; Buchel C.; Choi J.C.; Colloca L.; Duzzi D.; Eippert F.; Ellingsen D.-M.; Elsenbruch S.; Geuter S.; Kaptchuk T.J.; Kessner S.S.; Kirsch I.; Kong J.; Lamm C.; Leknes S.; Lui F.; Mullner-Huber A.; Porro C.A.; Rutgen M.; Schenk L.A.; Schmid J.; Theysohn N.; Tracey I.; Wrobel N.; Zeidan F.
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