Framework materials for full-arch implant-supported rehabilitations: A systematic review of clinical studies

The purpose of this systematic review was to investigate the clinical outcomes of frameworks made of different materials in patients with implant-supported full-arch prostheses. A literature search was conducted on MEDLINE, Scopus and Cochrane Library, until the 1st of March 2021, with the following search terms: framework or substructure combined with “dental implants”. The outcomes evaluated were: implant and prosthesis survival, bone resorption, biological and technical complications. The Cochrane Handbook for Systematic Reviews of Interventions was em-ployed to assess the risk of bias in randomized clinical trials. The Newcastle–Ottawa quality assessment scale was used for non-randomized studies. In total, 924 records were evaluated for title and abstract, and 11 studies were included in the review: 4 clinical randomized trials and 7 cohort stud-ies. The framework materials investigated were: gold alloy, titanium, silver-palladium alloy, zirco-nia and polymers including acrylic resin and carbon-fiber-reinforced composites. High implant and prosthetic cumulative survival rates were recorded by all included studies. Various materials and different fabrication techniques are now available as alternatives to traditional cast metal frame-works, for full-arch implant-supported rehabilitations. Further long-term studies are needed to val-idate the use of these materials and clarify their specific clinical indications and manufacturing pro-tocols to optimize their clinical outcomes.