Probing the high-x content of the nuclei in the fixed-target mode at the LHC

Using the LHCb and ALICE detectors in the fixed-target mode at the LHC offers unprecedented possibilities to study the quark, gluon and heavy-quark content of the proton and nuclei in the poorly known region of the high-momentum fractions. We review our projections for studies of Drell-Yan, charm, beauty and quarkonium production with both detector set-ups used with various nuclear targets and the LHC proton beams. Based on this, we show the expected improvement in the determination of the quark, charm and gluon proton and nuclear PDFs as well as discuss the implication for a better understanding of the cold-nuclear-matter effects in hard-probe production in proton-nucleus collisions.