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Comparing T Cell Subsets in Broncho-Alveolar Lavage (BAL) and Peripheral Blood in Patients with Advanced Lung Cancer

Articolo
Data di Pubblicazione:
2022
Abstract:
Background: Lung cancer (LC) tissue for immunological characterization is often scarce. We explored and compared T cell characteristics between broncho-alveolar lavage from tumor affected (t-BAL) and contralateral lung (cl-BAL), with matched peripheral blood (PB). Methods: BAL and PB were collected during bronchoscopy for diagnostic and/or therapeutic purposes in patients with monolateral primary lesion. Results: Of 33 patients undergoing BAL and PB sampling, 21 had histologically-confirmed LC. Most cases were locally-advanced or metastatic non-small cell LC. T cell characteristics were not significantly different in t-BAL vs. cl-BAL. Compared to PB, CD8 T cells in BAL presented features of immune activation and exhaustion (high PD-1, low IFN-g production). Accordingly, regulatory CD4 T cells were also higher in BAL vs. PB. When dichotomizing T cell density in t-BAL in high and low, we found that PD-L1 expression in LC was associated with T cell density in t-BAL. T-BAL with high T cell density had higher %IFN-g+CD8 T cells and lower %T-regs. Conclusion: In BAL from advanced LC patients, T cells present features of exhaustion. T cells in t-BAL could be the best surrogate of tumor-infiltrating T cell, and future studies should evaluate T cell phenotype and density as potential biomarkers for cancer immunotherapy outcome.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
BAL; PD-1; T cell; immunology; lung cancer; Humans; Bronchoalveolar Lavage Fluid; Programmed Cell Death 1 Receptor; Therapeutic Irrigation; T-Lymphocyte Subsets; Interferon-gamma; B7-H1 Antigen; Lung Neoplasms
Elenco autori:
Mariniello, Annapaola; Tabbò, Fabrizio; Indellicati, Davide; Tesauro, Martina; Rezmives, Nicole Alessia; Reale, Maria Lucia; Listì, Angela; Capelletto, Enrica; Carnio, Simona; Bertaglia, Valentina; Mecca, Caterina; Consito, Lorena; De Filippis, Marco; Bungaro, Maristella; Paratore, Chiara; Di Maio, Massimo; Passiglia, Francesco; Righi, Luisella; Sangiolo, Dario; Novello, Silvia; Geuna, Massimo; Bironzo, Paolo
Autori di Ateneo:
BIRONZO Paolo
DI MAIO Massimo
NOVELLO Silvia
PASSIGLIA Francesco
RIGHI Luisella
SANGIOLO Dario
Link alla scheda completa:
https://iris.unito.it/handle/2318/1878034
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1878034/1052406/cells-11-03226.pdf
Pubblicato in:
CELLS
Journal
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