Widespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks

Social gaze interaction powerfully shapes interpersonal communication. However, compared with social perception, very little is known about the neuronal underpinnings of real-life social gaze interaction. Here, we studied a large number of neurons spanning four regions in primate prefrontal-amygdala networks and demonstrate robust single-cell foundations of interactive social gaze in the orbitofrontal, dorsomedial pre-frontal, and anterior cingulate cortices, in addition to the amygdala. Many neurons in these areas exhibited high temporal heterogeneity for social discriminability, with a selectivity bias for looking at a conspecific compared with an object. Notably, a large proportion of neurons in each brain region parametrically tracked the gaze of self or other, providing substrates for social gaze monitoring. Furthermore, several neurons dis-played selective encoding of mutual eye contact in an agent-specific manner. These findings provide evi-dence of widespread implementations of interactive social gaze neurons in the primate prefrontal-amygdala networks during social gaze interaction.