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Oxidative Stress Trajectories during Lifespan: The Possible Mediation Role of Hormones in Redox Imbalance and Aging

Articolo
Data di Pubblicazione:
2023
Abstract:
Aging, a natural multifactorial process, increases Oxidative Stress (OS) and inflammatory responses. Sexual hormones could upregulate OS during lifespan, with opposite systemic effects: anti-oxidant protection and cellular pro-oxidant toxicity. Hormonal changes are crucial phases in human growth and aging, but their mediating role on OS is still incomplete. The main purpose of this work was to analyze the trend of OS during the lifespan and, in particular, during puberty and menopause. Data from standardized questionnaires and biological OS measurements (15-F2t-Isop) of 815 subjects (7–60 years old) from five previous studies (2009–2015) were analyzed. The age variable was categorized into two hormonal age windows: puberty and menopause. A regression model was performed to assess the association between 15-F2t-Isop and the hormonal age window, sex, weight, and smoking habits. The results showed a significant V-shape decrease of OS levels both during puberty [OR = -0.06 95% CI -0.07–-0.04, p = 0.41] and in menopause [OR = -1.01 95% CI -1.5–-0.5,p < 0.001], but only in females. Our results support the view that hormones, and specifically estrogen, could modulate OS, especially during puberty and menopause. The V-shape decreasing trend of OS may be related to intrinsic characteristics of estrogen, which is able to modulate and upregulate OS pro- and anti-oxidant mechanisms.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
oxidative stress; lifespan trend; hormonalwindows; puberty andmenopause; OS upregulation
Elenco autori:
Bono, Roberto; Squillacioti, Giulia; Ghelli, Federica; Panizzolo, Marco; Comoretto, Rosanna Irene; Dalmasso, Paola; Bellisario, Valeria
Autori di Ateneo:
BELLISARIO Valeria
BONO Roberto
COMORETTO Rosanna Irene
DALMASSO Paola
GHELLI Federica
PANIZZOLO MARCO
SQUILLACIOTI Giulia
Link alla scheda completa:
https://iris.unito.it/handle/2318/1886021
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1886021/1070991/sustainability-15-01814.pdf
Pubblicato in:
SUSTAINABILITY
Journal
  • Dati Generali
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Dati Generali

URL

https://www.mdpi.com/2071-1050/15/3/1814

Aree Di Ricerca

Settori (18)


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