Skip to Main Content (Press Enter)

Logo UNITO
  • ×
  • Home
  • Pubblicazioni
  • Progetti
  • Persone
  • Competenze
  • Settori
  • Strutture
  • Terza Missione

UNI-FIND
Logo UNITO

|

UNI-FIND

unito.it
  • ×
  • Home
  • Pubblicazioni
  • Progetti
  • Persone
  • Competenze
  • Settori
  • Strutture
  • Terza Missione
  1. Pubblicazioni

NO in Viral Infections: Role and Development of Antiviral Therapies

Articolo
Data di Pubblicazione:
2022
Abstract:
Nitric oxide is a ubiquitous signaling radical that influences critical body functions. Its importance in the cardiovascular system and the innate immune response to bacterial and viral infections has been extensively investigated. The overproduction of NO is an early component of viral infections, including those affecting the respiratory tract. The production of high levels of NO is due to the overexpression of NO biosynthesis by inducible NO synthase (iNOS), which is involved in viral clearance. The development of NO-based antiviral therapies, particularly gaseous NO inhalation and NO-donors, has proven to be an excellent antiviral therapeutic strategy. The aim of this review is to systematically examine the multiple research studies that have been carried out to elucidate the role of NO in viral infections and to comprehensively describe the NO-based antiviral strategies that have been developed thus far. Particular attention has been paid to the potential mechanisms of NO and its clinical use in the prevention and therapy of COVID-19.
Tipologia CRIS:
03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica
Keywords:
COVID-19; inhalation therapy; nitric oxide; NO-donors; viral infections
Elenco autori:
Sodano F.; Gazzano E.; Fruttero R.; Lazzarato L.
Autori di Ateneo:
GAZZANO Elena
LAZZARATO Loretta
Link alla scheda completa:
https://iris.unito.it/handle/2318/1888586
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1888586/1079778/2022_reviewantivirali_Molecules.pdf
Pubblicato in:
MOLECULES
Journal
  • Utilizzo dei cookie

Realizzato con VIVO | Designed by Cineca | 25.5.0.1