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The Surgical Risk Factors of Giant Intracranial Meningiomas: A Multi-Centric Retrospective Analysis of Large Case Serie

Articolo
Data di Pubblicazione:
2022
Abstract:
Giant intracranial meningiomas (GIMs) are a subgroup of meningiomas with huge dimensions with a maximum diameter of more than 5 cm. The mechanisms by which a meningioma can grow to be defined as a "giant" are unknown, and the biological, radiological profile and the different outcomes are poorly investigated. We performed a multi-centric retrospective study of a series of surgically treated patients suffering from intracranial meningioma. All the patients were assigned on the grounds of the preoperative imaging to giant and medium/large meningioma groups with a cut-off of 5 cm. We investigated whether the presence of large diameter and peritumoral brain edema (PBE) on radiological diagnosis indicates different mortality rates, grading, characteristics, and outcomes in a multi-variate analysis. We found a higher risk of developing complications for GIMs (29.9% versus 14.8%; p < 0.01). The direct proportional relationship between PBE volume and tumor volume was present only in the medium/large group (Pearson correlation with p < 0.01) and not in the GIM group (p = 0.47). In conclusion, GIMs have a higher risk of developing complications in the postoperative phase than medium/large meningioma without higher risk of mortality and recurrence.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
brain tumor; giant meningiomas; meningioma; peritumoral brain edema
Elenco autori:
Armocida, Daniele; Catapano, Antonia; Palmieri, Mauro; Arcidiacono, Umberto Aldo; Pesce, Alessandro; Cofano, Fabio; Picotti, Veronica; Salvati, Maurizio; Garbossa, Diego; D'Andrea, Giancarlo; Santoro, Antonio; Frati, Alessandro
Autori di Ateneo:
ARMOCIDA Daniele
COFANO Fabio
GARBOSSA Diego
Link alla scheda completa:
https://iris.unito.it/handle/2318/1901953
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1901953/1127529/The%20Surgical%20Risk%20Factors%20of%20Giant%20Intracranial%20Meningiomas-%20A%20Multi-Centric%20Retrospective%20Analysis%20of%20Large%20Case%20Serie.pdf
Pubblicato in:
BRAIN SCIENCES
Journal
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