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  1. Pubblicazioni

Linking neuroanatomical abnormalities in autism spectrum disorder with gene expression of candidate ASD genes: A meta-analytic and network-oriented approach

Articolo
Data di Pubblicazione:
2022
Abstract:
Background Autism spectrum disorder (ASD) is a set of developmental conditions with widespread neuroanatomical abnormalities and a strong genetic basis. Although neuroimaging studies have indicated anatomical changes in grey matter (GM) morphometry, their associations with gene expression remain elusive.Methods Here, we aim to understand how gene expression correlates with neuroanatomical atypicalities in ASD. To do so, we performed a coordinate-based meta-analysis to determine the common GM variation pattern in the autistic brain. From the Allen Human Brain Atlas, we selected eight genes from the SHANK, NRXN, NLGN family and MECP2, which have been implicated with ASD, particularly in regards to altered synaptic transmission and plasticity. The gene expression maps for each gene were built. We then assessed the correlation between the gene expression maps and the GM alteration maps. Lastly, we projected the obtained clusters of GM alteration-gene correlations on top of the canonical resting state networks, in order to provide a functional characterization of the structural evidence.Results We found that gene expression of most genes correlated with GM alteration (both increase and decrease) in regions located in the default mode network. Decreased GM was also correlated with gene expression of some ASD genes in areas associated with the dorsal attention and cerebellar network. Lastly, single genes were found to be significantly correlated with increased GM in areas located in the somatomotor, limbic and ganglia/thalamus networks.Conclusions This approach allowed us to combine the well beaten path of genetic and brain imaging in a novel way, to specifically investigate the relation between gene expression and brain with structural damage, and individuate genes of potential interest for further investigation in the functional domain.
Tipologia CRIS:
03A-Articolo su Rivista
Elenco autori:
Camasio, Alessia; Panzeri, Elisa; Mancuso, Lorenzo; Costa, Tommaso; Manuello, Jordi; Ferraro, Mario; Duca, Sergio; Cauda, Franco; Liloia, Donato
Autori di Ateneo:
BRISCHETTO COSTA Tommaso Carlo
CAUDA Franco
LILOIA DONATO
Link alla scheda completa:
https://iris.unito.it/handle/2318/1902096
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1902096/1127887/journal.pone.0277466.pdf
Pubblicato in:
PLOS ONE
Journal
  • Dati Generali
  • Aree Di Ricerca

Dati Generali

URL

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0277466

Aree Di Ricerca

Settori (28)


LS5_12 - Mental disorders - (2022)

LS5_16 - Systems and computational neuroscience - (2022)

LS5_17 - Imaging in neuroscience - (2022)

LS5_18 - Innovative methods and tools for neuroscience - (2022)

LS5_8 - Neural basis of behaviour - (2022)

SH4_1 - Cognitive basis of human development and education, developmental disorders; comparative cognition - (2022)

SH4_3 - Clinical and health psychology - (2022)

SH4_4 - Neuropsychology - (2022)

CIBO, AGRICOLTURA e ALLEVAMENTI - Farmacologia Veterinaria

CIBO, AGRICOLTURA e ALLEVAMENTI - Patologia e malattie degli animali

CIBO, AGRICOLTURA e ALLEVAMENTI - Scienze cliniche veterinarie

ECONOMIA, AZIENDE E ORGANIZZAZIONI - Economia del lavoro, della famiglia e di genere

ECONOMIA, AZIENDE E ORGANIZZAZIONI - Economia sperimentale, comportamentale e della complessità

ECONOMIA, AZIENDE E ORGANIZZAZIONI - Storia e Metodologia dell'Economia

LINGUE e LETTERATURA - Linguistica

MEDICINA, SALUTE e BENESSERE - Diagnostica e Imaging

MEDICINA, SALUTE e BENESSERE - Disturbi neuropsichiatrici

MEDICINA, SALUTE e BENESSERE - Epidemiologia

MEDICINA, SALUTE e BENESSERE - Fisiologia comportamentale

MEDICINA, SALUTE e BENESSERE - Malattie neurologiche e neurodegenerative

MEDICINA, SALUTE e BENESSERE - Oncologia e Tumori

MEDICINA, SALUTE e BENESSERE - Prevenzione e corretti stili di vita

MEDICINA, SALUTE e BENESSERE - Psicologia clinica

MEDICINA, SALUTE e BENESSERE - Ricerca Traslazionale e Clinica

SCIENZE DELLA VITA e FARMACOLOGIA - Interazioni tra molecole, cellule, organismi e ambiente

SCIENZE DELLA VITA e FARMACOLOGIA - Sviluppo del sistema nervoso e plasticità

SCIENZE MATEMATICHE, CHIMICHE, FISICHE - Storia e insegnamento della Matematica

STORIA, FILOSOFIA ed EDUCAZIONE - Educazione e didattica innovative
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