Skip to Main Content (Press Enter)

Logo UNITO
  • ×
  • Home
  • Pubblicazioni
  • Progetti
  • Persone
  • Competenze
  • Settori
  • Strutture
  • Terza Missione

UNI-FIND
Logo UNITO

|

UNI-FIND

unito.it
  • ×
  • Home
  • Pubblicazioni
  • Progetti
  • Persone
  • Competenze
  • Settori
  • Strutture
  • Terza Missione
  1. Pubblicazioni

Can oestrogenic activity in air contribute to the overall body burden of endocrine disruptors?

Articolo
Data di Pubblicazione:
2023
Abstract:
Endocrine disruptors (EDCs) are emerging contaminants that are harmful to health. Human exposure occurs mainly through ingestion or dermal contact, but inhalation could be an additional exposure route; therefore, this study was conducted to evaluate the oestrogenic activity of airborne particulate matter (PM). Outdoor PM was collected for a year in five Italian sites and extracted with organic solvents (four seasonal extracts/site). The oestrogenic activity was assessed using a gene reporter assay (MELN), and the risk to human health through inhalation was quantified using the results. Moreover, extracts were analysed to assess cytotoxicity (WST-1 and LDH assays) on human bronchial cells (BEAS-2B). The extracts induced a significant cytotoxicity and oestrogenic activity. Oestrogenic activity showed a seasonal trend and was correlated with concentrations of benzo(a)pyrene and toxic equivalency factor. Although a low inhalation cancer risk was found, this study confirmed that oes-trogenic activity in air could contribute to overall health risks due to EDC exposure.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Cytotoxicity; Endocrine disrupting chemicals; In vitro assay; MELN cells; Particulate matter; Risk assessment
Elenco autori:
Gea, Marta; Macri, Manuela; Marangon, Daniele; Pitasi, Francesco Antonio; Fontana, Marco; Bonetta, Sara; Schiliro, Tiziana
Autori di Ateneo:
BONETTA Sara
SCHILIRO' Tiziana
Link alla scheda completa:
https://iris.unito.it/handle/2318/1928156
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1928156/1181862/Articolo%20Gea%20et%20al.%202023_PM%20oestrogenic%20effect.pdf
Pubblicato in:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Journal
  • Aree Di Ricerca

Aree Di Ricerca

Settori (14)


LS7_11 - Environmental health, occupational medicine - (2022)

CIBO, AGRICOLTURA e ALLEVAMENTI - Farmacologia Veterinaria

CIBO, AGRICOLTURA e ALLEVAMENTI - Patologia e malattie degli animali

CIBO, AGRICOLTURA e ALLEVAMENTI - Scienze cliniche veterinarie

MEDICINA, SALUTE e BENESSERE - Disturbi neuropsichiatrici

MEDICINA, SALUTE e BENESSERE - Epidemiologia

MEDICINA, SALUTE e BENESSERE - Malattie neurologiche e neurodegenerative

MEDICINA, SALUTE e BENESSERE - Medicina Rigenerativa e Cellule Staminali

MEDICINA, SALUTE e BENESSERE - Oncologia e Tumori

MEDICINA, SALUTE e BENESSERE - Ricerca Traslazionale e Clinica

MEDICINA, SALUTE e BENESSERE - Trapianti e medicina rigenerativa

SCIENZE DELLA VITA e FARMACOLOGIA - Interazioni tra molecole, cellule, organismi e ambiente

SCIENZE DELLA VITA e FARMACOLOGIA - Molecole bioattive

SCIENZE DELLA VITA e FARMACOLOGIA - Sviluppo del sistema nervoso e plasticità
  • Utilizzo dei cookie

Realizzato con VIVO | Designed by Cineca | 25.6.1.0