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  1. Pubblicazioni

Short-Term Effect of Nutraceutical Fruit Juices on Lipid Metabolism in Patients with Acquired Hypercholesterolemia

Articolo
Data di Pubblicazione:
2023
Abstract:
The crucial role of dyslipidaemia, especially hypercholesterolemia, in the development of atherosclerosis-related cardiovascular diseases has been extensively documented in genetic, pathologic, observational and intervention studies. The European guidelines for dyslipidaemia management include the possible use of lipid-lowering nutraceuticals to support a relatively large number of natural compounds. In this context, we have conducted a study to investigate whether dietary supplementation with a functional nutraceutical beverage, containing a standardized polyphenolic fraction from fruit, red yeast rice, phytosterols, and berberine complexed with beta-cyclodextrin, could positively affect serum lipid concentration in 14 subjects with hypercholesterolemia. After 12 weeks of treatment, dietary supplementation with this nutraceutical combination was associated with significant improvements in total cholesterol, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol (non-HDL-C) and apolipoprotein B, compared to baseline. Compliance was excellent and no adverse effects were reported. In conclusion, this study demonstrates that 100 mL of a functional beverage containing lipid-lowering nutraceuticals safely leads to significant improvements in serum lipids in subjects with moderate hypercholesterolemia. Future research is needed to unravel the role that the polyphenols contained in fruit extracts play in the reduction of cholesterolemia and in cardiovascular disease prevention.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
berberine-cyclodextrin complex; fruit juices; hypercholesterolemia; phytosterols; polyphenols; red yeast rice
Elenco autori:
Ardissino, Diego; Colletti, Alessandro; Pellizzato, Marzia; Pagliari, Gianna; Di Pierro, Francesco; Cravotto, Giancarlo
Autori di Ateneo:
CRAVOTTO Giancarlo
Link alla scheda completa:
https://iris.unito.it/handle/2318/1951094
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1951094/1227036/ijms-24-07358-v2.pdf
Pubblicato in:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Journal
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  • Aree Di Ricerca

Dati Generali

URL

https://www.mdpi.com/1422-0067/24/8/7358

Aree Di Ricerca

Settori (20)


LS4_9 - Metabolism and metabolic disorders, including diabetes and obesity - (2022)

LS9_5 - Food biotechnology and bioengineering - (2022)

CIBO, AGRICOLTURA e ALLEVAMENTI - Agricoltura e Produzioni Vegetali

CIBO, AGRICOLTURA e ALLEVAMENTI - Allevamento e Produzioni Animali

CIBO, AGRICOLTURA e ALLEVAMENTI - Chimica e cibo

CIBO, AGRICOLTURA e ALLEVAMENTI - Farmacologia Veterinaria

CIBO, AGRICOLTURA e ALLEVAMENTI - Miglioramento e difesa delle colture

CIBO, AGRICOLTURA e ALLEVAMENTI - Patologia e malattie degli animali

CIBO, AGRICOLTURA e ALLEVAMENTI - Scienze cliniche veterinarie

CIBO, AGRICOLTURA e ALLEVAMENTI - Tecnologie alimentari e microbiologia degli alimenti

CULTURA, ARTE e CREATIVITA' - Culture moderne

MEDICINA, SALUTE e BENESSERE - Epidemiologia

MEDICINA, SALUTE e BENESSERE - Oncologia e Tumori

MEDICINA, SALUTE e BENESSERE - Ricerca Traslazionale e Clinica

MEDICINA, SALUTE e BENESSERE - Trapianti e medicina rigenerativa

PIANETA TERRA, AMBIENTE, CLIMA, ENERGIA e SOSTENIBILITA' - Energia e Fonti Energetiche

PIANETA TERRA, AMBIENTE, CLIMA, ENERGIA e SOSTENIBILITA' - Foreste e Legno

PIANETA TERRA, AMBIENTE, CLIMA, ENERGIA e SOSTENIBILITA' - Risorsa suolo e ambiente

SCIENZE DELLA VITA e FARMACOLOGIA - Interazioni tra molecole, cellule, organismi e ambiente

SCIENZE DELLA VITA e FARMACOLOGIA - Tecnologie Farmaceutiche e Cosmetiche
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