Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis
Articolo
Data di Pubblicazione:
2022
Abstract:
Background: Thymic carcinoma is a rare and highly malignant tumor with a dismal prognosis, which occasionally coexists with myasthenia gravis (MG). This study aims to investigate the MG incidence on a surgical cohort of patients with thymic carcinoma and to explore its influence on long-term survival. Methods: the prospectively collected data from the ESTS database on thymic epithelial tumors were reviewed. Clinical, pathological, and survival information on thymic carcinoma were analyzed. Results: the analysis was conducted on 203 patients, with an equal gender distribution (96 males and 107 females). MG was detected in 22 (10.8%) patients, more frequently elderly (>60 years, p = 0.048) and male (p = 0.003). Induction therapy was performed in 22 (10.8%) cases. After surgery, 120 (59.1%) patients had a Masaoka stage II–III while complete resection (R0) was achieved in 158 (77.8%). Adjuvant therapy was performed in 68 cases. Mean follow-up was 60 (SD = 14) months. The 3-year, 5-year and 10-year survival rates were 79%, 75% and 63%, respectively. MG did not seem to influence long-term survival (5-year survival in non-MG–TCs 78% vs. 50% in MG–TCs, p = ns) as age < 60 years, female gender, early Masaoka stage, and postoperative radiotherapy did, conversely. Conclusions: myasthenia occurred in about 10% of thymic carcinomas and it did not seem to affect significantly the long-term prognosis in surgically treated thymic carcinoma-patients.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
myasthenia gravis; recurrence; surgery; thymic carcinoma
Elenco autori:
Lococo F.; Nachira D.; Chiappetta M.; Evangelista J.; Falcoz P.E.; Ruffini E.; Van Schil P.; Scarci M.; Furak J.; Sollitto F.; Guerrera F.; Spaggiari L.; Aigner C.; Evangelia L.; Bille A.; Moser B.; Thomas P.A.; Liberman M.; Boubia S.; Campisi A.; Ampollini L.; Toker A.; Enyed A.; Voltolini L.; Van Raemdonck D.; Margaritora S.
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