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Serum vitamin d as a marker of impaired information processing speed and early disability in multiple sclerosis patients

Articolo
Data di Pubblicazione:
2021
Abstract:
Slowed information processing speed (IPS) is the hallmark and first cognitive domain to be altered in multiple sclerosis (MS) patients. Insufficient serum vitamin D was previously associated with disease development, relapses, and progression, but little is reported on cognition. However, vitamin D and cognitive impairment (CI) in other neurodegenerative diseases have already been linked. We explored the possible correlation between vitamin D and IPS at diagnosis and early disability at last follow-up in 81 MS patients. At diagnosis, we collected vitamin D levels and performed a Symbol Digit Modalities Test (SDMT). Raw scores were adjusted for age, gender, and educational level. Early disability was evaluated with MS severity score (MSSS) and age-related MSSS (ARMSS). A total of 71 patients (86.58%) showed hypovitaminosis D (19.71 ± 8.76 ng/mL) and 18 patients (21.95%) had CI. Patients with CI showed severe hypovitaminosis D (p = 0.004). No patients with sufficient vitamin D levels had CI. We found a positive correlation between vitamin D levels at diagnosis and (1) SDMT raw and z-score that persisted after correction for sunlight exposure and MRI baseline characteristics, and (2) EDSS, MSSS, and ARMSS after a mean 2 year follow-up. Low vitamin D levels may affect both cognition and early disability in newly diagnosed MS patients.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Cognition; Information processing speed; IPS; Multiple sclerosis; SDMT; Symbol digit modalities test; Vitamin D
Elenco autori:
Virgilio E.; Vecchio D.; Crespi I.; Barbero P.; Caloni B.; Naldi P.; Cantello R.; Dianzani U.; Comi C.
Autori di Ateneo:
VIRGILIO Eleonora
Link alla scheda completa:
https://iris.unito.it/handle/2318/2022650
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/2022650/1392548/brainsci-11-01521.pdf
Pubblicato in:
BRAIN SCIENCES
Journal
  • Aree Di Ricerca

Aree Di Ricerca

Settori (22)


LS5_11 - Neurological and neurodegenerative disorders - (2024)

LS5_15 - Neuroimmunology, neuroinflammation - (2024)

LS7_2 - Medical technologies and tools (including genetic tools and biomarkers) for prevention, diagnosis, monitoring and treatment of diseases - (2024)

SH4_4 - Neurocognitive psychology - (2024)

CIBO, AGRICOLTURA e ALLEVAMENTI - Farmacologia Veterinaria

CIBO, AGRICOLTURA e ALLEVAMENTI - Patologia e malattie degli animali

CIBO, AGRICOLTURA e ALLEVAMENTI - Scienze cliniche veterinarie

LINGUE e LETTERATURA - Linguistica

MEDICINA, SALUTE e BENESSERE - Diagnostica e Imaging

MEDICINA, SALUTE e BENESSERE - Disturbi neuropsichiatrici

MEDICINA, SALUTE e BENESSERE - Epidemiologia

MEDICINA, SALUTE e BENESSERE - Fisiologia comportamentale

MEDICINA, SALUTE e BENESSERE - Malattie neurologiche e neurodegenerative

MEDICINA, SALUTE e BENESSERE - Medicina Rigenerativa e Cellule Staminali

MEDICINA, SALUTE e BENESSERE - Oncologia e Tumori

MEDICINA, SALUTE e BENESSERE - Psicologia clinica

MEDICINA, SALUTE e BENESSERE - Ricerca Traslazionale e Clinica

MEDICINA, SALUTE e BENESSERE - Trapianti e medicina rigenerativa

SCIENZE DELLA VITA e FARMACOLOGIA - Basi molecolari e cellulari delle patologie

SCIENZE DELLA VITA e FARMACOLOGIA - Interazioni tra molecole, cellule, organismi e ambiente

SCIENZE DELLA VITA e FARMACOLOGIA - Molecole bioattive

SCIENZE DELLA VITA e FARMACOLOGIA - Sviluppo del sistema nervoso e plasticità
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