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  1. Pubblicazioni

Reciprocal Dynamics of Metabolism and mRNA Translation in Tumor Angiogenesis

Articolo
Data di Pubblicazione:
2024
Abstract:
Angiogenesis, the process of formation of new blood vessels from pre-existing vasculature, is essential for tumor growth and metastasis. Anti-angiogenic treatment targeting vascular endothelial growth factor (VEGF) signaling is a powerful tool to combat tumor growth; however, anti-tumor angiogenesis therapy has shown limited efficacy, with survival benefits ranging from only a few weeks to months. Compensation by upregulation of complementary growth factors and switches to different modes of vascularization have made these types of therapies less effective. Recent evidence suggests that targeting specific players in endothelial metabolism is a valuable therapeutic strategy against tumor angiogenesis. Although it is clear that metabolism can modulate the translational machinery, the reciprocal relationship between metabolism and mRNA translational control during tumor angiogenesis is not fully understood. In this review, we explore emerging examples of how endothelial cell metabolism affects mRNA translation during the formation of blood vessels. A deeper comprehension of these mechanisms could lead to the development of innovative therapeutic strategies for both physiological and pathological angiogenesis.
Tipologia CRIS:
03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica
Keywords:
endothelial cell metabolism; mRNA translation; tumor vasculature
Elenco autori:
Lidonnici J.; Oberkersch R.E.
Autori di Ateneo:
OBERKERSCH Roxana Elena
Link alla scheda completa:
https://iris.unito.it/handle/2318/2075701
Pubblicato in:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Journal
  • Dati Generali
  • Aree Di Ricerca

Dati Generali

URL

https://www.mdpi.com/1422-0067/25/20/11284

Aree Di Ricerca

Settori (9)


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