Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study
Articolo
Data di Pubblicazione:
2023
Abstract:
Background: Kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS). Objective: To investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB). Methods: Patients with PPMS were recruited through 11 MS centres across 7 countries. κ-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation. Results: A total of 174 patients (mean age of 52±11 years, 51% males) were included. κ-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients. Conclusion: κ-FLC index shows similar diagnostic sensitivity than OCB in PPMS.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
cerebrospinal fluid; diagnosis; kappa free light chain; multiple sclerosis; primary progressive; sensitivity
Elenco autori:
Hegen, Harald; Berek, Klaus; Cavalla, Paola; Christiansen, Mikael; Emeršič, Andreja; Di Filippo, Massimiliano; Gaetani, Lorenzo; Hassler, Michaela; Leurs, Cyra; Milosavljevic, Dejan; van Pesch, Vincent; Petersen, Thor; Presslauer, Stefan; Rosenstein, Igal; Rot, Uroš; Schnabl, Christine; Teunissen, Charlotte; Vecchio, Domizia; Vercellino, Marco; Deisenhammer, Florian
Link alla scheda completa:
Link al Full Text:
Pubblicato in: