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  1. Pubblicazioni

Surgical and oncological management of renal medullary carcinoma in a young patient: a case report

Articolo
Data di Pubblicazione:
2023
Abstract:
Renal medullary carcinoma (RMC) is a rare form of renal cell carcinoma that has a poor prognosis. It is known to be associated with sickle cell trait or disease, although the exact underlying mechanisms are still unclear. The diagnosis is made through immunochemical staining for SMARCB1 (INI1). In this report, we present a case of a 31-year-old male patient with sickle cell trait who was diagnosed with stage III right RMC. Despite the poor prognosis, the patient survived for a remarkable duration of 37 months. Radiological assessment and follow-up were primarily performed using 18F-FDG PET/MRI. The patient underwent upfront cisplatin-based cytotoxic chemotherapy before surgical removal of the right kidney and retroperitoneal lymph node dissection. Identical adjuvant chemotherapy was administered post-surgery. Disease relapses were detected in the retroperitoneal lymph nodes; these were managed with chemotherapy and surgical rechallenges. We also discuss the oncological and surgical management of RMC, which currently relies on perioperative cytotoxic chemotherapy strategies, as there are no known alternative therapies that have been shown to be superior to date.
Tipologia CRIS:
03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica
Keywords:
SMARCB1; chemotherapy; non-clear cell RCC; onco-urological management; renal medullary carcinoma
Elenco autori:
Courcier, Jean; De La Taille, Alexandre; Bertolo, Riccardo; Amparore, Daniele; Erdem, Selcuk; Kara, Onder; Marchioni, Michele; Pavan, Nicola; Roussel, Eduard; Mamodaly, Maria; Campi, Riccardo; Ingels, Alexandre
Autori di Ateneo:
AMPARORE Daniele
Link alla scheda completa:
https://iris.unito.it/handle/2318/2079382
Pubblicato in:
FRONTIERS IN ONCOLOGY
Journal
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