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Cross-species comparisons of nanoparticle interactions with innate immune systems: A methodological review

Articolo
Data di Pubblicazione:
2021
Abstract:
Many components of the innate immune system are evolutionarily conserved and shared across many living organisms, from plants and invertebrates to humans. Therefore, these shared features can allow the comparative study of potentially dangerous substances, such as engineered nanoparticles (NPs). However, differences of methodology and procedure between diverse species and models make comparison of innate immune responses to NPs between organisms difficult in many cases. To this aim, this review provides an overview of suitable methods and assays that can be used to measure NP immune interactions across species in a multidisciplinary approach. The first part of this review describes the main innate immune defense characteristics of the selected models that can be associated to NPs exposure. In the second part, the different modes of exposure to NPs across models (considering isolated cells or whole organisms) and the main endpoints measured are discussed. In this synergistic perspective, we provide an overview of the current state of important cross-disciplinary immunological models to study NP-immune interactions and identify future research needs. As such, this paper could be used as a methodological reference point for future nano-immunosafety studies.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Environmental models; Human cells; Innate immunity; Markers; NPs testing
Elenco autori:
Swartzwelter B.J.; Mayall C.; Alijagic A.; Barbero F.; Ferrari E.; Hernadi S.; Michelini S.; Pacheco N.I.N.; Prinelli A.; Swart E.; Auguste M.
Autori di Ateneo:
BARBERO FRANCESCO
Link alla scheda completa:
https://iris.unito.it/handle/2318/2082896
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/2082896/1904267/2021_Swartzwelter_rev_et-al.pdf
Pubblicato in:
NANOMATERIALS
Journal
  • Aree Di Ricerca

Aree Di Ricerca

Settori (16)


LS7_3 - Nanomedicine - (2024)

LS7_7 - Pharmacology and toxicology - (2024)

PE11_9 - Nanomaterials engineering, e.g. nanoparticles, nanoporous materials, 1D & 2D nanomaterials - (2024)

CIBO, AGRICOLTURA e ALLEVAMENTI - Farmacologia Veterinaria

CIBO, AGRICOLTURA e ALLEVAMENTI - Patologia e malattie degli animali

CIBO, AGRICOLTURA e ALLEVAMENTI - Scienze cliniche veterinarie

MEDICINA, SALUTE e BENESSERE - Disturbi neuropsichiatrici

MEDICINA, SALUTE e BENESSERE - Epidemiologia

MEDICINA, SALUTE e BENESSERE - Malattie neurologiche e neurodegenerative

MEDICINA, SALUTE e BENESSERE - Medicina Rigenerativa e Cellule Staminali

MEDICINA, SALUTE e BENESSERE - Oncologia e Tumori

MEDICINA, SALUTE e BENESSERE - Ricerca Traslazionale e Clinica

MEDICINA, SALUTE e BENESSERE - Trapianti e medicina rigenerativa

SCIENZE DELLA VITA e FARMACOLOGIA - Interazioni tra molecole, cellule, organismi e ambiente

SCIENZE DELLA VITA e FARMACOLOGIA - Molecole bioattive

SCIENZE DELLA VITA e FARMACOLOGIA - Sviluppo del sistema nervoso e plasticità
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