Calming down T cell acute leukemia.

Signaling from class I phosphoinositide 3-kinase (PI3K) is often deregulated in leukemia and lymphoma, but which isoforms are involved in T cell acute lymphoblastic leukemia (T-ALL) was not known. In this issue of Cancer Cell, Subramaniam et al. show that T-ALL can be tamed by inhibiting γ and δ PI3K isoforms.