Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

Adenocarcinoma; Adenocarcinoma of Lung; Aged; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cisplatin; Dasatinib; Discoidin Domain Receptor 1; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Male; Membrane Proteins; Mice; Middle Aged; Mutation; Neoplasm Transplantation; Neoplasms, Experimental; Paclitaxel; Proto-Oncogene Proteins p21(ras); Receptor Protein-Tyrosine Kinases; Receptors, Notch; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction