Molecular Mechanisms of Curcumin in the Pathogenesis of Metabolic Dysfunction Associated Steatotic Liver Disease
Articolo
Data di Pubblicazione:
2023
Abstract:
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multifactorial condition characterized by insulin resistance, oxidative stress, chronic low-grade inflammation, and
sometimes fibrosis. To date, no effective pharmacological therapy has been approved for the treatment
of metabolic-associated steatohepatitis (MASH), the progressive form of MASLD. Recently, numerous
in vitro and in vivo studies have described the efficacy of nutraceutical compounds in the diet has
been tested. Among them, curcumin is the most widely used polyphenol in the diet showing potent
anti-inflammatory and antifibrotic activities. This review aims to summarize the most important
basic studies (in vitro and animal models studies), describing the molecular mechanisms by which
curcumin acts in the context of MASLD, providing the rationale for its effective translational use
in humans.
Tipologia CRIS:
03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica
Keywords:
curcumin; hepatic fibrosis; inflammation; insulin resistance; metabolic dysfunction associated steatotic liver disease; nutraceuticals; oxidative stress
Elenco autori:
Marta Guariglia, Francesca Saba, Chiara Rosso, Elisabetta Bugianesi
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