Aneuploidy frequently manifests in the aggressive variant of Triple Negative Breast Cancer (TNBC). Within the
spectrum of factors influencing altered ploidy, failure of cytokinesis and subsequent tetraploidization
represent driving events affecting cancer evolution. This process endows cancer cells with a tetraploid status
conducive to the sustained accumulation of genetic abnormalities during subsequent rounds of cell division.
Dysregulated phosphoinositide (PtdIns) metabolism emerges as a central mechanism among the various
factors leading to cytokinesis failure and the generation of tetraploid cells.