Yb(III)-HPDO3A: A Dual pH- and Temperature-Responsive CEST Agent

A multiple response: Yb III-HPDO3A has been used for the development of a magnetic resonance imaging method that is able to assess pH value and temperature simultaneously, irrespective of the concentration of the complex (see graph). This contrast agent has potential in a clinical setting as it shows the same stability and invivo pharmacokinetic properties as Gd III-HPDO3A, which is already used in clinical practices under the trade name of ProHance.