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NAD+-metabolizing ecto-enzymes shape tumor-host interactions: the chronic lymphocytic leukemia model.

Articolo
Data di Pubblicazione:
2011
Abstract:
Nicotinamide adenine dinucleotide (NAD(+)) is an essential co-enzyme that can be released in the extracellular milieu. Here, it may elicit signals through binding purinergic receptors. Alternatively, NAD(+) may be dismantled to adenosine, up-taken by cells and transformed to reconstitute the intracellular nucleotide pool. An articulated ecto-enzyme network is responsible for the nucleotide-nucleoside conversion. CD38 is the main mammalian enzyme that hydrolyzes NAD(+), generating Ca(2+)-active metabolites. Evidence suggests that this extracellular network may be altered or used by tumor cells to (i) nestle in protected areas, and (ii) evade the immune response. We have exploited chronic lymphocytic leukemia as a model to test the role of the ecto-enzyme network, starting by analyzing the individual elements that make up the whole picture.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
NAD+; CD38; Chronic lymphocytic leukemia; Proliferation; Chemotaxis; Homing
Elenco autori:
Vaisitti T; Audrito V; Serra S; Bologna C; Brusa D; Malavasi F; Deaglio S
Autori di Ateneo:
DEAGLIO Silvia
VAISITTI Tiziana
Link alla scheda completa:
https://iris.unito.it/handle/2318/91302
Pubblicato in:
FEBS LETTERS
Journal
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URL

http://dx.doi.org/10.1016/j.febslet.2011.04.036; http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T36-52NBSFF-2-1&_cdi=4938&_user=525216&_pii=S0014579311002833&_origin=&_coverDate=06%2F06%2F2011&_sk=994149988&view=c&wchp=dGLzVzz-zSkWb&md5=6c2f60b3205ab0b9ec5498c6626b480f&ie=/sdarticle.pdf
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