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Immune response to acetaldehyde-human serum albumin adduct among healthy subjects related to alcohol intake

Articolo
Data di Pubblicazione:
2013
Abstract:
Acetaldehyde (AA) is the main metabolic product in ethanol metabolism, although it can also derive from sources of airborne pollution. As a typical aldehyde, AA is able to react with a variety of molecular targets, including DNA and protein. This property justifies the hypothesis of a immune reaction against this kind of adduct, to be studied by a seroprevalence screening approach. In this study, the correlation between drinking habits and the amount of circulating AA-Human Serum Albumin adduct (AA-HSA) was evaluated in a group of healthy subjects, non alcohol-addicted. Daily ethanol intake (grams) was inferred for each subject using the information collected through a questionnaire, and AA-HSA antibodies (AA-HSA ab) analyses were performed using the Displacement Assay on whole blood samples. The findings showed a correlation between ethanol intake and immune response to molecular adduct . These results underscore the evaluation of AA-HSA ab amount as a suitable molecular marker for alcohol intake that can be applied in future investigations on a large scale for prevention screening.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Acetaldehyde, Ethanol, Immune response, Molecular adduct
Elenco autori:
Valeria Romanazzi; Tiziana SchilirĂ²; Elisabetta Carraro; Giorgio Gilli
Autori di Ateneo:
CARRARO Elisabetta
SCHILIRO' Tiziana
Link alla scheda completa:
https://iris.unito.it/handle/2318/136365
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/136365/49656/Immune_response.pdf
Pubblicato in:
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Journal
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Dati Generali

URL

http://dx.doi.org/10.1016/j.etap.2013.05.002
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