Folic Acid in the Solid State: A Synergistic Computational, Spectroscopic, and Structural Approach

The structure of crystalline folic acid·2H2O has been investigated by a synergistic approach combining Raman spectroscopy, X-ray powder diffraction, and cutting-edge calculation methods. Comparison of the computed and measured Raman spectra was used to support the proposed solid-state structure. Folic acid·2H2O has also been used in the preparation, via solvent free methods, of amorphous multicomponent materials and salts.