Cellular senescence markers p16INK4 and p21CIP1/WAF are predictors of Hodgkin's lymphoma outcome

There is evidence that Hodgkin Reed-Sternberg (HRS) cells in classical Hodgkin's lymphoma (cHL) could display some molecular and morphological markers of cellular senescence (CS). We hypothesized that CS mechanisms may have potential prognostic relevance in cHL and investigated whether the expression of the well-established CS biomarkers p21CIP1/WAF1 and p16INK4a by HRS cells might be predictive of the probability of event-free survival (EFS).