Data di Pubblicazione:
2017
Abstract:
Unprecedented fast and efficient complexation of ScIIIwas demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the44Sc(AAZTA)−chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
kinetics; PET; radiopharmaceuticals; scandium; thermodynamics;
Elenco autori:
Nagy G, Szikra D, Trencsényi G, Fekete A, Garai I, Giani AM, Negri R, Masciocchi N, Maiocchi A, Uggeri F, Tóth I, Aime S, Giovenzana GB, Baranyai Z.
Link alla scheda completa:
Pubblicato in: