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  1. Pubblicazioni

Where do we stand after decades of studying human cytomegalovirus?

Articolo
Data di Pubblicazione:
2020
Abstract:
Human cytomegalovirus (HCMV), a linear double-stranded DNA betaherpesvirus belonging to the family of Herpesviridae, is characterized by widespread seroprevalence, ranging between 56% and 94%, strictly dependent on the socioeconomic background of the country being considered. Typically, HCMV causes asymptomatic infection in the immunocompetent population, while in immunocompromised individuals or when transmitted vertically from the mother to the fetus it leads to systemic disease with severe complications and high mortality rate. Following primary infection, HCMV establishes a state of latency primarily in myeloid cells, from which it can be reactivated by various inflammatory stimuli. Several studies have shown that HCMV, despite being a DNA virus, is highly prone to genetic variability that strongly influences its replication and dissemination rates as well as cellular tropism. In this scenario, the few currently available drugs for the treatment of HCMV infections are characterized by high toxicity, poor oral bioavailability, and emerging resistance. Here, we review past and current literature that has greatly advanced our understanding of the biology and genetics of HCMV, stressing the urgent need for innovative and safe anti-HCMV therapies and effective vaccines to treat and prevent HCMV infections, particularly in vulnerable populations.
Tipologia CRIS:
03B-Review in Rivista / Rassegna della Lett. in Riv. / Nota Critica
Keywords:
Antiviral therapy; Genetic variability; Human cytomegalovirus; Pathogenesis; Viral dissemination
Elenco autori:
Gugliesi Francesca, Coscia Alessandra, Griffante Gloria, Galitska Ganna, Pasquero Selina, Albano Camilla, Biolatti Matteo
Autori di Ateneo:
ALBANO CAMILLA
BIOLATTI Matteo
COSCIA Alessandra
GRIFFANTE Gloria
GUGLIESI Francesca
PASQUERO SELINA
Link alla scheda completa:
https://iris.unito.it/handle/2318/1740741
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1740741/614909/microorganisms-08-00685.pdf
Pubblicato in:
MICROORGANISMS
Journal
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URL

https://www.mdpi.com/2076-2607/8/5/685
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