Data di Pubblicazione:
2008
Abstract:
Abstract: The article addresses the design of multitarget drugs, namely compounds capable of interacting with more than one target simultaneously. These agents could be useful tools in the therapy of complex diseases such as cardiovascular and inflammatory diseases. An interesting case of multitarget compounds are nitric oxide (NO)-donor hybrids, structures which combine the physiological properties of NO with those of a lead drug. In particular the authors discuss the symbiotic approach used to design NO-donor non-steroidal anti-inflammatory drugs (NO-NSAIDs) and NO-donor antioxidants. The former could be useful agents in the treatment of anti-inflammatory diseases being devoid of gastro- and cardiotoxicity, the latter could be a valid approach to the treatment of many cardiovascular diseases.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Multitarget drugs; NO-donor hybrid drugs; NO-NSAIDs; NO-antioxidants; NO-donors; nitric oxide (NO)
Elenco autori:
Alberto Gasco; Donatella Boschi; Konstantin Chegaev; Clara Cena; Antonella Di Stilo; Roberta Fruttero; Loretta Lazzarato; Barbara Rolando; Paolo Tosco
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