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Lenalidomide-based triplet regimens in first relapsed multiple myeloma patients: real-world evidence from a propensity score matched analysis

Articolo
Data di Pubblicazione:
2022
Abstract:
: Lenalidomide and dexamethasone (Rd)-based triplets, in particular Carfilzomib-Rd (KRd) and Daratumumab-Rd (DaraRd), represent a standard of care in lenalidomide sensitive multiple myeloma (MM) patients in first relapse. Meta-analysis of randomized clinical trials (RCT), suggested better outcome with DaraRd. Trying to address this issue in clinical practice, we collected data of 430 consecutive MM patients addressed to Rd-based triplets in first relapse between January 2017 and March 2021. Overall, the most common used regimen was DaraRd, chosen in almost half of the cases (54.4%), followed by KRd (34.6%). Different triplets were used much less commonly. In the attempt to limit the imbalance of a retrospective analysis, we conducted a propensity score matching (PSM) comparison between DaraRd and KRd. After PSM, efficacy of DaraRd vs KRd was similar in terms of overall response rate (ORR) (OR: 0.9, p=0.685) as well as of very good partial response (VGPR) or better (OR: 0.9, p=0.582). The median progression-free survival (PFS) was significantly longer for DaraRd (29.8 vs 22.5 months; p=0.028). DaraRd was better tolerated, registering a lower rate of grade 3-4 non-hematological toxicity (OR: 0.4, p.
Tipologia CRIS:
03A-Articolo su Rivista
Elenco autori:
Mangiacavalli, Silvia; Cartia, Claudio Salvatore; Galli, Monica; Pezzatti, Sara; Belotti, Angelo; Fazio, Francesca; Mina, Roberto; Marcatti, Magda; Cafro, Anna; Zambello, Renato; Paris, Laura; BarilĂ , Gregorio; Olivares, Cecilia; Pompa, Alessandra; Mazza, Rita; Farina, Francesca; Soldarini, Martina; Benvenuti, Pietro; Pagani, Giuseppina; Palumbo, Michele; Masoni, Valeria; Ferretti, Virginia Valeria; Klersy, Catherine; Arcaini, Luca; Petrucci, Maria Teresa
Autori di Ateneo:
MINA Roberto
Link alla scheda completa:
https://iris.unito.it/handle/2318/1890112
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1890112/1141019/[Published%20Vsn]%20Mangiacavalli%20et%20al%20-%202022%20-%20Haematologica%20-%20Lenalidomide-based%20triplet%20regimens.pdf
Pubblicato in:
HAEMATOLOGICA
Journal
  • Dati Generali
  • Aree Di Ricerca

Dati Generali

URL

https://haematologica.org/article/view/haematol.2022.281342; https://doi.org/10.3324/haematol.2022.281342

Aree Di Ricerca

Settori (10)


LS4_11 - Haematopoiesis and blood diseases - (2022)

LS4_12 - Cancer - (2022)

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