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Intracellular Ca2+ signalling: unexpected new roles for the usual suspect

Articolo
Data di Pubblicazione:
2023
Abstract:
Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ concentration ([Ca2+](i)) are finely tuned by the concerted interaction of membrane receptors and ion channels that introduce Ca2+ into the cytosol, Ca2+-dependent sensors and effectors that translate the elevation in [Ca2+](i) into a biological output, and Ca2+-clearing mechanisms that return the [Ca2+](i) to pre-stimulation levels and prevent cytotoxic Ca2+ overload. The assortment of the Ca2+ handling machinery varies among different cell types to generate intracellular Ca2+ signals that are selectively tailored to subserve specific functions. The advent of novel high-speed, 2D and 3D time-lapse imaging techniques, single-wavelength and genetic Ca2+ indicators, as well as the development of novel genetic engineering tools to manipulate single cells and whole animals, has shed novel light on the regulation of cellular activity by the Ca2+ handling machinery. A symposium organized within the framework of the 72nd Annual Meeting of the Italian Society of Physiology, held in Bari on 14-16th September 2022, has recently addressed many of the unexpected mechanisms whereby intracellular Ca2+ signalling regulates cellular fate in healthy and disease states. Herein, we present a report of this symposium, in which the following emerging topics were discussed: 1) Regulation of water reabsorption in the kidney by lysosomal Ca2+ release through Transient Receptor Potential Mucolipin 1 (TRPML1); 2) Endoplasmic reticulum-to-mitochondria Ca2+ transfer in Alzheimer's disease-related astroglial dysfunction; 3) The non-canonical role of TRP Melastatin 8 (TRPM8) as a Rap1A inhibitor in the definition of some cancer hallmarks; and 4) Non-genetic optical stimulation of Ca2+ signals in the cardiovascular system.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Ca2+ signalling; TRP channels; lysosomal Ca2+; mitochondria-ER contact sites; non-canonical signalling; optical stimulation
Elenco autori:
Moccia, Francesco; Fiorio Pla, Alessandra; Lim, Dmitry; Lodola, Francesco; Gerbino, Andrea
Autori di Ateneo:
FIORIO PLA Alessandra
Link alla scheda completa:
https://iris.unito.it/handle/2318/1954751
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1954751/1235032/fphys-14-1210085.pdf
Pubblicato in:
FRONTIERS IN PHYSIOLOGY
Journal
Progetto:
MUNARON Luca Maria - MIUR - PRIN 2017 Linea A - Leveraging basic knowledge of ion channel network in cancer for innovative therapeutic strategies (LIONESS)
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Settori (9)


LS3_16 - Functional imaging of cells and tissues - (2022)

CIBO, AGRICOLTURA e ALLEVAMENTI - Allevamento e Produzioni Animali

CIBO, AGRICOLTURA e ALLEVAMENTI - Farmacologia Veterinaria

CIBO, AGRICOLTURA e ALLEVAMENTI - Patologia e malattie degli animali

MEDICINA, SALUTE e BENESSERE - Epidemiologia

MEDICINA, SALUTE e BENESSERE - Oncologia e Tumori

MEDICINA, SALUTE e BENESSERE - Ricerca Traslazionale e Clinica

MEDICINA, SALUTE e BENESSERE - Trapianti e medicina rigenerativa

SCIENZE DELLA VITA e FARMACOLOGIA - Interazioni tra molecole, cellule, organismi e ambiente
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